Los inicios de la bacteriología en Buenos Aires en el siglo XIX: transformaciones institucionales y políticas sanitarias / [The beginnings of bacteriology in Buenos Aires in the 19th century: institutional transformations and health policies]

En este trabajo se analiza el comienzo de la incorporación de la bacteriología a la política sanitaria en Buenos Aires durante las décadas de 1880 y 1890, y las transformaciones que este proceso implicó en el plano institucional y de la intervención estatal. En particular, indagamos en estos cambios a través de la creación y los primeros años de funcionamiento de dos espacios orientados a la producción y enseñanza de conocimientos bacteriológicos: el Laboratorio Bacte-riológico de la Asistencia Pública y la Sección Bacteriológica de la Oficina Sanitaria Argentina. A través del estudio de las trayectorias de los creadores y primeros integrantes de ambos espacios, un grupo de la élite médica agrupada en el Círculo Médico Argentino, y de los conocimientos que circularon al interior de ambas instituciones, reconstruimos el inicio del desarrollo de la bacteriología en Argentina y el modo en que se incorporó a las agendas gubernamentales. (AU)

[Robert Koch as a young rural doctor in Brandenburg and the Poznan region (1868-1880)]. / Robert Koch als junger Landarzt in Brandenburg und Posen (1868­1880).

The bacteriologist and Nobel Prize winner Robert Koch (1843-1910) is one of the most important and best-known scientists in German history. Many people associate him not only with the institute named after him (today the Robert Koch Institute is Germany's National Public Health Institute), but above all, with his work as a "microbe hunter". Koch achieved world fame with the discovery of the tuberculosis pathogen in 1882. To research and combat infectious diseases, he undertook expeditions to foreign countries. This article deals with a lesser-known episode in Robert Koch's life - his years as a young rural doctor in the then Prussian provinces of Brandenburg and Posen. After a chronological description of Robert Koch's "wandering years", the focus is directed to today's culture of remembrance. The question is discussed in which way, if at all, the memory of Robert Koch is maintained at the authentic places.

Erin Goley.

Interview with Erin Goley, who studies the mechanisms governing bacterial morphogenesis and the regulation of bacterial growth in changing environments at Johns Hopkins University School of Medicine.

[Jules Bordet, a man of conviction. Centenary of his Nobel Prize]. / Jules Bordet, un homme de conviction - Centenaire de l'attribution de son prix Nobel.

Jules Bordet came to the Institut Pasteur soon after his MD graduation at the Université libre de Bruxelles, thanks to a grant from the Belgian government. He joined there the laboratory of Elie Metchnikoff, the father of phagocytes and cellular immunity. Amazingly, he will decipher there some of the key mechanisms of humoral immunity initially discovered by the German school against which his mentor was fighting. He described the mechanisms that govern bacteriolysis and hemolysis, following the action of immune sera. Even if he favored the term alexin coined by Hans Buchner, he is indeed one of the founding fathers of the complement system (term coined by Paul Ehrlich). It is for these works that he was awarded in October 1920 the 1919 Nobel Prize. Back in Belgium, he became the director of Institut Pasteur du Brabant and made another landmark discovery, namely the identification of the bacillus of whooping cough, now named Bordetella pertussis.

TITLE: Jules Bordet, un homme de conviction - Centenaire de l'attribution de son prix Nobel. ABSTRACT: Docteur en médecine, bénéficiant d'une bourse du gouvernement belge, Jules Bordet vint se former au sein du laboratoire du père de l'immunité cellulaire, Elie Metchnikoff, à l'Institut Pasteur. Paradoxalement, il va y déchiffrer certains des mécanismes clés de l'immunité humorale, initialement découverte par l'école allemande. Il y décrit notamment les mécanismes qui aboutissent à la bactériolyse et l'hémolyse par l'action d'immunsérums. Même s'il favorisa le terme d'alexine, créé par Hans Buchner, c'est bien le système du complément (terme inventé par Paul Ehrlich) dont il est un des pères fondateurs. C'est pour ces travaux qu'il se verra attribué en octobre 1920 le prix Nobel de physiologie ou médecine millésimé 1919. Il identifia aussi le bacille de la coqueluche, qui porte son nom Bordetella pertussis.

After Pettenkofer. Munich's Institute of Hygiene and the long shadow of National Socialism, 1894-1974.

The year 2019 marked the 140th anniversary of the inauguration of the first Institute of Hygiene, which was established for Max von Pettenkofer at the university of Munich. After Pettenkofer, his successors tried to advance the science of hygiene each in their own specific way, highlighting different aspects and trying to relate them to Pettenkofer's legacy: Max von Gruber promoted an understanding of hygiene which was more and more tied to constitutional and racial factors, Karl Kisskalt tried to revise a perceived bacteriological paradigm, and Hermann Eyer focused on preventive public health measures. All of those influences had a more or less explicit and distinct connection to the general development of German medicine in the first half of the 20th century and its culmination in National Socialist crimes. The history of Munich's Institute of Hygiene after Pettenkofer illustrates the differing scientific and ideological paths this development pursued by the examples of its three long-term protagonists and their relationship to National Socialism.

Jules Bordet: immunologist, bacteriologist and Nobel Prize winner.

This year marks the 150th anniversary of the birth of Jules Jean Baptiste Vincent Bordet, to give him his full name, the Belgian immunologist and bacteriologist.

Tuberculosis, Cholera, Anthrax: Dreadful Culprits.

Dreadful culprits from the minuscule world, indeed, but … what about poverty, war, and terrorism in the macroscopic nowadays world?

Letters from Libman: Dispatches from an American Abroad.

American physician Emanuel Libman (1872-1946) was a generalist with Sherlockian diagnostic skills ("secret-divining eyes" according to Einstein) whose achievements were recognized by the scientific community and the public. Personal aspects of Libman were revealed in an oral history conducted with psychiatrist George L. Engel, a nephew who was raised in his house, and show Libman to be an intensely private person, contrasting with the image of him as a mentor and teacher. Yet Libman as a young physician and investigator remains absent in these opposing biographical reflections. His papers housed at the National Library of Medicine contain a series of letters sent home from his year of postgraduate study in Europe in 1897. These letters, which have not been previously described in the medical literature, create a window into the experiences of a young American physician abroad. Libman's letters create a framework for understanding a typical European course of study for American physicians while tracing his career and personal development. Specifically, his correspondence highlights foundational experiences in bacteriology and pathology and explores his encounters with European anti-Semitism. The letters reveal a young doctor interested in history and sightseeing, awed by medical luminaries, concerned about establishing a career, and increasingly aware of intolerance.

The Way It Was.

Mary Osborn was a native Californian. She was an undergraduate at the University of California, Berkeley, where she worked in the laboratory of I.L. Chaikoff. She received her PhD at the University of Washington, where her work on the role of folic acid coenzymes in one-carbon metabolism revealed the mechanism of action of methotrexate. After postdoctoral training with Bernard Horecker in the Department of Microbiology at New York University (NYU), she embarked on her research career as a faculty member in the NYU Department of Microbiology and in the Department of Molecular Biology at Albert Einstein College of Medicine. In 1968 she moved as one of the founding faculty of the new medical school of the University of Connecticut, where she remained until her retirement in 2014. Her research was focused on the biosynthesis of the endotoxin lipopolysaccharide (LPS) of gram-negative bacteria and on the assembly of the bacterial cell envelope. She made seminal contributions in these areas. She was the recipient of numerous honors and served as president of several important scientific organizations. Later in her career she served as chair of the National Research Council Committee on Space Biology and Medicine, advisory to the National Aeronautics and Space Administration (NASA), which produced an influential report that plotted the path for NASA's space biology research program in the first decade of the twenty-first century. Dr. Osborn died on Jan. 17, 2019.

[Pediatrics and travel culture: Spanish travel award-holders and the appropriation of laboratories on the periphery, 1907-1939]. / Pediatría y cultura de viaje: los pensionados españoles y la apropiación del laboratorio en la periferia, 1907-1939.

Starting from the hypothesis that laboratories played an important role in pediatrics becoming an autonomous discipline, this article studies the influence of scientific travel on the appropriation of new methodologies by Spanish pediatricians and child-care experts in the first third of the twentieth century. To do so, it analyzes the travel awards granted by the Junta para Ampliación de Estudios e Investigaciones Científicas. It describes the scientific geography created by the program and takes an in-depth look at the role of mentors - especially Gustavo Pittaluga (1876-1956) - in this process. In addition to a prosopographical study of the group, it presents three cases that demonstrate the importance of the program in bringing pediatrics into contact with bacteriology, pathological anatomy and biochemistry.

Partiendo de la hipótesis de que el laboratorio jugó un papel importante en la autonomía disciplinar de la pediatría, este artículo estudia la influencia del viaje científico en la apropiación de nuevas metodologías por parte de los pediatras y puericultores españoles del primer tercio del siglo XX. Para ello, se analizan las pensiones concedidas a tal efecto por la Junta para Ampliación de Estudios e Investigaciones Científicas. Se describe la geografía científica creada por el programa y se profundiza en el papel de los mentores ­ especialmente de Gustavo Pittaluga (1876-1956) ­ en este proceso. Además de un estudio prosopográfico del grupo, se presentan tres casos que demuestran la importancia del programa en el encuentro de la pediatría con la bacteriología, la anatomía patológica y la bioquímica.

Pediatría y cultura de viaje: los pensionados españoles y la apropiación del laboratorio en la periferia, 1907-1939 / Pediatrics and travel culture: Spanish travel award-holders and the appropriation of laboratories on the periphery, 1907-1939

Resumen Partiendo de la hipótesis de que el laboratorio jugó un papel importante en la autonomía disciplinar de la pediatría, este artículo estudia la influencia del viaje científico en la apropiación de nuevas metodologías por parte de los pediatras y puericultores españoles del primer tercio del siglo XX. Para ello, se analizan las pensiones concedidas a tal efecto por la Junta para Ampliación de Estudios e Investigaciones Científicas. Se describe la geografía científica creada por el programa y se profundiza en el papel de los mentores - especialmente de Gustavo Pittaluga (1876-1956) - en este proceso. Además de un estudio prosopográfico del grupo, se presentan tres casos que demuestran la importancia del programa en el encuentro de la pediatría con la bacteriología, la anatomía patológica y la bioquímica.

Abstract Starting from the hypothesis that laboratories played an important role in pediatrics becoming an autonomous discipline, this article studies the influence of scientific travel on the appropriation of new methodologies by Spanish pediatricians and child-care experts in the first third of the twentieth century. To do so, it analyzes the travel awards granted by the Junta para Ampliación de Estudios e Investigaciones Científicas. It describes the scientific geography created by the program and takes an in-depth look at the role of mentors - especially Gustavo Pittaluga (1876-1956) - in this process. In addition to a prosopographical study of the group, it presents three cases that demonstrate the importance of the program in bringing pediatrics into contact with bacteriology, pathological anatomy and biochemistry.

The "Petri" Dish: A Case of Simultaneous Invention in Bacteriology.

Richard Julius Petri's status as inventor of the culture dish that bears his name has been subject to a number of challenges over the years. Both those bacteriologists who claimed self-recognition for the invention, and those to whom it was attributed by their various advocates were all contemporaries of Petri. The evidence assembled here indicates that no single individual-including Petri-ought to be accorded credit for the inception of that shallow, circular, covered culture dish which, it transpires, is a simultaneous invention made by half a dozen bacteriologists active in the mid-1880s and ultimately owes its emergence to the prevailing bacteriological zeitgeist.

[Leonhard Riedmüller: Swiss public enemy or pawn sacrifice?] / Leonhard Riedmüller: Schweizer Staatsfeind oder Bauernopfer?

INTRODUCTION: On June 9, 1945 the Zurich cantonal government issued the lifetime deportation from Switzerland for Prof. Dr. med. vet. Leonhard Riedmüller (1898-1976) and his spouse Helena, née Eltze (1910-1990), both German citizens on grounds of Riedmüllers' membership in the NSDAP, "Landesgruppe Schweiz". Riedmüllers' several attempts to appeal at court were not successful. Riedmüllers biography shows that he served in the German Army at the Western front during WW I. Following the war he studied Veterinary Medicine at the University of Munich where he received the degree of Dr. med. vet. Moving to Zurich in 1926, Riedmüller took a position as veterinary bacteriologist at the University of Zurich. In 1941 he was promoted and became head of the Institute of Veterinary Bacteriology. He left Europe in 1947 for Brazil and took a position as a veterinary bacteriologist at a government laboratory. After retiring from his position in Brazil he returned to Germany where he passed away in 1976. Based on available documents from several Swiss archives the question is discussed whether Riedmüllers' deportation as public enemy in 1945 was appropriate or if Swiss authorities might have been tempted to sacrifice Riedmüller as a pawn in consideration of Switzerlands international political position immediately after the end of WW II.